How do tissue-specific chaperone networks determine differential vulnerability to the same protein misfolding variant?

The debate identified chaperone system differences as a key mechanism but failed to establish which specific chaperone components drive tissue selectivity. Understanding these networks is essential for developing tissue-targeted protein folding therapies. Source: Debate session sess_SDA-2026-04-08-gap-pubmed-20260406-062222-b5f44522 (Analysis: SDA-2026-04-08-gap-pubmed-20260406-062222-b5f44522)