What paracrine factors mediate ARAP3-dependent microglial-astrocyte crosstalk and their astrocyte subtype effects?

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Description

The debate proposed ARAP3 modulation creates beneficial paracrine signaling but never identified the specific secreted factors or their astrocyte receptors. This mechanistic gap prevents rational drug design targeting the microglial-astrocyte axis.

Source: Debate session sess_SDA-2026-04-10-sda-2026-04-01-gap-007 (Analysis: sda-2026-04-01-gap-007)

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