How do microglial state transitions determine whether TNF-α/IL-6 signaling is protective or pathogenic?

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Description

The debate proposed that cytokine function depends on microglial phenotype but acknowledged this oversimplifies the spectrum of microglial states. The molecular determinants of when these cytokines switch from beneficial to harmful remain uncharacterized.

Source: Debate session sess_SDA-2026-04-08-gap-debate-20260406-062045-ce866189 (Analysis: SDA-2026-04-08-gap-debate-20260406-062045-ce866189)

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