Can TYROBP stabilization maintain TREM2 signaling independently of surface receptor expression levels?

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50%

Description

The hypothesis assumes TYROBP stabilization can bypass TREM2 ectodomain loss, but the debate did not establish whether downstream signaling can be maintained without adequate surface receptor density. This mechanistic question is fundamental to the therapeutic approach’s viability.

Source: Debate session sess_sda-2026-04-01-001 (Analysis: sda-2026-04-01-001)

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