How does lactylation of ARF1 mechanistically regulate LRP1-mediated mitochondrial transfer efficiency?

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Description

The LRP1-ARF1 lactylation axis was identified as crucial for mitochondrial transfer regulation, but the debate noted the mechanistic connection between lactylation inhibition and enhanced transfer remains poorly established. This limits therapeutic targeting.

Source: Debate session sess_sda-2026-04-01-gap-v2-89432b95 (Analysis: sda-2026-04-01-gap-v2-89432b95)

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