Do NMDA receptor-mediated circuit dysfunctions operate independently of spine loss and structural degeneration?

Evidence suggested NMDA receptors mediate synaptic depression but not spine loss, indicating multiple independent pathways. The debate didn't clarify how these functional and structural pathways interact or whether they require different therapeutic approaches. Source: Debate session sess_SDA-2026-04-03-26abc5e5f9f2 (Analysis: SDA-2026-04-03-26abc5e5f9f2)