What are the long-term safety implications of chronic PARP1 modulation in the aging brain?

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Description

The Domain Expert raised concerns about cancer risk and cognitive impairment from PARP inhibitors, but no long-term CNS safety data exists. This knowledge gap is critical given AD requires chronic treatment in elderly populations.

Source: Debate session sess_SDA-2026-04-02-gap-seaad-v2-20260402032945 (Analysis: SDA-2026-04-02-gap-seaad-v2-20260402032945)

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