How do circadian rhythm disruptions mechanistically impair glymphatic clearance of tau and amyloid-beta?

While the debate acknowledged that circadian disruption affects glymphatic function, the specific molecular mechanisms linking circadian clock dysfunction to reduced protein clearance remain unclear. This knowledge gap limits development of targeted chronotherapeutic interventions. Source: Debate session sess_SDA-2026-04-02-gap-20260402-003115 (Analysis: SDA-2026-04-02-gap-20260402-003115)