What CNS penetration strategies can achieve therapeutic concentrations of proteostasis enhancers?

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Description

The domain expert noted poor CNS penetration of existing autophagy enhancers like rapamycin, but alternative delivery methods weren’t explored. This pharmacokinetic barrier represents a major obstacle to translating proteostasis-based therapies.

Source: Debate session sess_SDA-2026-04-01-gap-012 (Analysis: SDA-2026-04-01-gap-012)

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