The P2X7 hypothesis relies on TRIM46-mediated actin polymerization in astrocytes, but TRIM46 is established as neuronal-specific for microtubule organization. This fundamental molecular gap undermines the proposed mechanism and requires direct validation in astrocytic cultures. Source: Debate session sess_sda-2026-04-01-gap-20260401231108_20260412-084542 (Analysis: sda-2026-04-01-gap-20260401231108)
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debate:sess_sda-2026-04-01-gap-20260401231108_20260412-084542
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