Extracellular vesicles (EVs), including exosomes and microvesicles, carry molecular cargo (proteins, miRNAs, lipids) from their cells of origin, including neurons, astrocytes, and microglia. Brain-derived EVs can cross the blood-brain barrier and be isolated from blood, CSF, or saliva, potentially serving as liquid biopsy biomarkers for Alzheimer disease. Key questions: Which EV-derived biomarkers (e.g., phospho-tau, amyloid-beta, synaptic proteins, inflammatory mediators) show the highest diagnostic accuracy for early/prodromal AD? How do EV subpopulations (neuronal vs glial origin) differ in their biomarker profiles? What are the technical challenges in EV isolation and characterization that limit clinical translation?
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Scores
Composite
0.850
Importance
0.900
Tractability
0.850
Novelty
0.800
Priority
0.920
Market Price
0.500