How does focal demyelination of trigeminal afferents lead to hyperexcitable neuronal states and central sensitization?

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Description

While focal demyelination is identified as a key etiological factor and hyperexcitable states are described as pathophysiological features, the mechanistic link between peripheral demyelination and central nervous system changes remains unexplained. This gap limits understanding of disease progression and potential intervention points.

Gap type: unexplained_observation Source paper: Trigeminal neuralgia. (2024, Nature reviews. Disease primers, PMID:38816415)

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