What is the causal relationship between HCN1 alteration and epileptogenesis?

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Description

The authors explicitly state this causal relationship ‘has not been elucidated’ despite clear correlations between decreased HCN1 expression and epilepsy. Understanding causality versus consequence is critical for determining whether HCN1 is a therapeutic target or biomarker.

Gap type: open_question Source paper: The Impact of Altered HCN1 Expression on Brain Function and Its Relationship with Epileptogenesis. (2023, Curr Neuropharmacol, PMID:37366350)

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