What mechanisms drive the accumulation of non-CG methylation specifically in neurons but not glia during development?

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Description

The abstract reveals that mCH accumulates exclusively in neurons during fetal to young adult development, becoming the dominant methylation form in human neuronal genomes. The cellular mechanisms underlying this neuron-specific epigenetic phenomenon remain unexplained.

Gap type: unexplained_observation Source paper: Global epigenomic reconfiguration during mammalian brain development. (2013, Science, PMID:23828890)

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