What mechanisms drive the selective increase in complete/near-complete responses with panobinostat?

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Priority

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Market price

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Description

Panobinostat significantly increased complete/near-complete responses (27.6% vs 15.7%) while overall response rates were similar. The biological basis for this quality-of-response improvement is unclear but critical for understanding optimal combination strategies.

Gap type: unexplained_observation Source paper: Panobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double-blind phase 3 trial. (2014, The Lancet. Oncology, PMID:25242045)

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