Why does panobinostat improve progression-free survival but not overall response rates in multiple myeloma?

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Description

The study shows significant PFS improvement (11.99 vs 8.08 months) but no difference in overall response rates (60.7% vs 54.6%). This disconnect between disease control and response metrics suggests unknown mechanisms of panobinostat action that need clarification for optimal patient selection.

Gap type: unexplained_observation Source paper: Panobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double-blind phase 3 trial. (2014, The Lancet. Oncology, PMID:25242045)

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