How does IDH2 gain-of-function mechanistically stabilize HIF-1α through reductive glutamine metabolism?

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Description

The abstract shows IDH2 gain-of-function induces reductive glutamine metabolism that stabilizes HIF-1α, but the specific molecular mechanism linking these processes is not explained. Understanding this pathway is critical for developing targeted therapies that disrupt this stabilization.

Gap type: unexplained_observation Source paper: IDH2 stabilizes HIF-1α-induced metabolic reprogramming and promotes chemoresistance in urothelial cancer. (2023, EMBO J, PMID:36637036)

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