How do extensive matrix remodeling changes coordinate with adhesion signaling to drive radioresistance?

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Description

The abstract reveals that radioresistance involves both extracellular matrix remodeling and changes in adhesion signaling proteins, but how these two processes are coordinated mechanistically is not explained. This coordination likely represents a key vulnerability for therapeutic targeting.

Gap type: unexplained_observation Source paper: The extracellular matrix component perlecan/HSPG2 regulates radioresistance in prostate cancer cells. (2024, Front Cell Dev Biol, PMID:39149513)

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