How do NTRK2 gene-gene interactions contribute to suicidal behavior risk?

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Description

The authors explicitly identify gene-gene interactions as unexplored territory that could explain NTRK2’s role in suicidality. Understanding these interactions is crucial since individual SNP effects may be masked by epistatic relationships in neurotrophic signaling pathways.

Gap type: open_question Source paper: Association of NTRK2 gene with suicidality: a meta-analysis. (2024, Psychiatric genetics, PMID:39527116)

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