Description
This study shows cGAMP provides neuroprotection, contradicting established literature where cGAS-STING activation typically drives harmful neuroinflammation in stroke and neurodegeneration. The factors determining this protective versus destructive switch remain unknown, yet this knowledge is essential for therapeutic targeting of the pathway.
Gap type: contradiction Source paper: cGAMP Enhances Microglial/Macrophage Phagocytosis in Ischemic Stroke Via Activation of the TREM2-DAP10-PI3K Pathway. (2026, Inflammation, PMID:41495583)
Evidence summary
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