How do plasma levels of synaptic and vascular proteins relate to their brain tissue concentrations in preclinical AD?

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Description

The authors note these markers were previously only reliably measured in CSF, raising questions about the relationship between peripheral and central levels. This validation gap is critical for interpreting plasma biomarker results and establishing their clinical utility.

Gap type: open_question Source paper: Multi-analyte proteomic analysis identifies blood-based neuroinflammation, cerebrovascular and synaptic biomarkers in preclinical Alzheimer’s disease. (2024, medRxiv : the preprint server for health sciences, PMID:38947065)

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