How does OX2R C-terminal dysfunction contribute to depression and anorexia pathogenesis?

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Description

The authors suggest the C-terminus may be associated with depression and anorexia, but provide no mechanistic link between the observed signaling defects and these neuropsychiatric conditions. This gap limits translation of receptor structure-function insights into therapeutic targets.

Gap type: open_question Source paper: C-terminus of OX2R significantly affects downstream signaling pathways. (None, None, PMID:28487995)

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