What neurobiological mechanisms underlie differential drug efficacy in psychotic versus non-psychotic depression?

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Description

The abstract reveals a lack of specific drug recommendations for psychotic depression, suggesting standard antidepressants may work differently when psychosis is present. Understanding the distinct neurobiological pathways could inform targeted treatment approaches for this severe depression subtype.

Gap type: open_question Source paper: Pharmacological treatments for psychotic depression: a systematic review and network meta-analysis. (None, None, PMID:38360024)

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