What determines when tPA's effects are plasmin-dependent versus plasmin-independent in the ischemic brain?

cerebrovascular disease open
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Description

The abstract describes tPA having both fibrinolytic (plasmin-dependent) and non-fibrinolytic effects, but doesn’t explain what molecular or contextual factors determine which pathway predominates. Understanding this switch mechanism is critical for developing targeted stroke therapies that preserve beneficial effects while minimizing harmful ones.

Gap type: unexplained_observation Source paper: Fibrinolytic and Non-fibrinolytic Roles of Tissue-type Plasminogen Activator in the Ischemic Brain. (2024, Neuroscience, PMID:37574107)

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