What mechanisms coordinate tPA release from multiple cell types during cerebral ischemia?

cerebrovascular disease open
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Description

The abstract states that ischemia triggers rapid tPA release from endothelial cells, astrocytes, microglia, and neurons simultaneously, but doesn’t address how this multi-cellular response is coordinated. Understanding this coordination is essential for predicting and modulating the overall tPA response in stroke.

Gap type: unexplained_observation Source paper: Fibrinolytic and Non-fibrinolytic Roles of Tissue-type Plasminogen Activator in the Ischemic Brain. (2024, Neuroscience, PMID:37574107)

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