How do NMDAR and LRP-1 receptors differentially mediate tPA's contradictory effects on neuronal survival?

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Description

The abstract mentions tPA has ‘various effects on neuronal survival’ mediated by NMDAR and LRP-1, but doesn’t explain how the same receptors can produce both protective and detrimental outcomes. This mechanistic gap limits rational design of receptor-selective interventions for stroke treatment.

Gap type: unexplained_observation Source paper: Fibrinolytic and Non-fibrinolytic Roles of Tissue-type Plasminogen Activator in the Ischemic Brain. (2024, Neuroscience, PMID:37574107)

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