What causes the age-related decline in autophagy-related gene expression in neurogenic niches?

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Description

The study identifies decreased autophagy gene expression and activity in aged SVZ/SGZ regions but does not explain what drives this decline. Understanding the upstream regulators of autophagy loss during aging could reveal new therapeutic targets for maintaining neurogenesis throughout life.

Gap type: unexplained_observation Source paper: Activation of Autophagy Ameliorates Age-Related Neurogenesis Decline and Neurodysfunction in Adult Mice. (2022, Stem cell reviews and reports, PMID:34546510)

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