What mechanisms explain mustard honey's superior antidepressant efficacy compared to fluoxetine in behavioral tests?

neuropsychiatry open
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Description

Mustard honey showed comparable or better effects than fluoxetine despite targeting the same TrkB/BDNF pathway. The mechanistic basis for this enhanced efficacy through polyphenol action versus SSRI mechanisms remains unexplained.

Gap type: unexplained_observation Source paper: Phytoconstituents of Indian mustard honey impart antidepressant activity in reserpine-induced depressed condition through activation of TrkB/CREB/BDNF pathway in hippocampus. (2026, Nutritional neuroscience, PMID:41017663)

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