What mechanisms explain how β-catenin mutations can be both oncogenic and tumor suppressive in cancer?

cancer biology open
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Description

The abstract reports both gain-of-function and loss-of-function CTNNB1 mutations are detected in human cancers, presenting a paradox. Understanding this dual role is critical for developing targeted therapies and predicting treatment responses in β-catenin-driven diseases.

Gap type: contradiction Source paper: Multi‑layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β‑catenin signaling activation (Review). (None, None, PMID:29786110)

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