How do voltage-gated calcium channels mechanistically link sex-specific pathological modules in trigeminal neuralgia?

neuropathic pain open
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Description

While PPI analysis identifies calcium channel subunits as central hubs connecting male and female pathological networks, the specific molecular interactions and signaling cascades remain undefined. This mechanistic gap limits understanding of how calcium channel modulation achieves therapeutic effects.

Gap type: unexplained_observation Source paper: Phosphoproteomics uncovers a neuroimmune perspective on trigeminal neuralgia: sexually dimorphic regulatory networks linking calcium channels to the complement cascade. (2026, Frontiers in immunology, PMID:41853292)

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