Why does impaired microglial phagocytosis specifically increase spontaneous seizure frequency?

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Description

The correlation between reduced phagocytic activity and increased spontaneous seizures suggests accumulated damaged neurons drive epileptogenesis, but the specific mechanisms by which uncleared neuronal debris promotes seizure generation are unknown. This gap limits understanding of chronic epilepsy development.

Gap type: unexplained_observation Source paper: Microglial TREM2 promotes phagocytic clearance of damaged neurons after status epilepticus. (2025, Brain, behavior, and immunity, PMID:39353548)

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