How does intranasal delivery achieve preferential targeting to peri-infarct regions versus healthy brain tissue?

drug delivery open
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Description

The study shows increased circSCMH1 distribution in peri-infarct regions via intranasal delivery, but the mechanism for this selective targeting is unexplained. This knowledge gap limits optimization of delivery strategies and understanding of nose-to-brain transport in stroke conditions.

Gap type: unexplained_observation Source paper: Nose-to-Brain Delivery of Circular RNA SCMH1-Loaded Lipid Nanoparticles for Ischemic Stroke Therapy. (2025, Advanced materials (Deerfield Beach, Fla.), PMID:40143778)

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