Why does oligodendroglial hyperplasia occur in both Emx1 and Olig2 lineage knockouts despite different seizure outcomes?

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Description

Both conditional knockout models show increased oligodendroglial cell density, yet only the Emx1 model produces clear seizures while Olig2 knockout shows abnormal EEG without seizures. The mechanistic basis for this oligodendroglial hyperplasia and its relationship to epileptogenesis remains unclear.

Gap type: unexplained_observation Source paper: Mouse models of Slc35a2 brain mosaicism reveal mechanisms of mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy. (2024, Epilepsia, PMID:39460689)

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