The study demonstrates persistent microgliosis associated with severe myelin loss and corpus callosum thinning, but the causal mechanisms linking chronic microglial activation to white matter pathology remain unexplained. This knowledge gap limits therapeutic targeting of white matter protection. Gap type: unexplained_observation Source paper: Deleterious effect of sustained neuroinflammation in pediatric traumatic brain injury. (2024, Brain, behavior, and immunity, PMID:38705494)
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