The study reveals that pTau enhances EV release in a Gal3-dependent manner, suggesting Gal3 controls EV biogenesis, but the underlying cellular machinery and signaling pathways are not characterized. This gap limits understanding of how tau pathology spreads between cells. Gap type: unexplained_observation Source paper: Galectin-3 aggravates microglial activation and tau transmission in tauopathy. (2024, The Journal of clinical investigation, PMID:37988169)
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pubmed:37988169
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