How do protein-protein interaction networks mediate the causal effects of distant pQTLs?

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Description

The authors reveal an extensive network of direct protein-protein interactions and identify second proteins/transcripts as causal mediators of distant pQTL effects. The mechanistic basis of how these interaction networks propagate genetic effects across the proteome is not elucidated, representing a critical gap for understanding disease susceptibility networks.

Gap type: unexplained_observation Source paper: Defining the consequences of genetic variation on a proteome-wide scale. (2016, Nature, PMID:27309819)

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