HMW tau triggers robust microglial responses including Clec7a-positive rod microglia formation, yet doesn't cause neurodegeneration or synapse loss unlike fibrillar tau. This dissociation between neuroinflammation and neuronal damage challenges current understanding of tau toxicity mechanisms. Gap type: unexplained_observation Source paper: Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau. (2023, Acta neuropathologica, PMID:37341831)
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pubmed:37341831
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Importance
0.880
Tractability
0.820
Priority
0.860
Market Price
0.500