Why do some L1CAM-negative EVs still contain neuronal proteins, and what is their cellular origin?

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Description

The finding that 0.8-3.9% of L1CAM-negative EVs carry neuronal proteins challenges the assumption that L1CAM is universally expressed on neuron-derived EVs. This could indicate either neuronal EVs that lack L1CAM or cross-contamination, with important implications for biomarker specificity.

Gap type: unexplained_observation Source paper: Single-extracellular vesicle (EV) analyses validate the use of L1 Cell Adhesion Molecule (L1CAM) as a reliable biomarker of neuron-derived EVs. (2024, Journal of extracellular vesicles, PMID:38868956)

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