Atlas · Knowledge gaps

Knowledge gaps queue

Open research questions ranked by priority. Each gap is a candidate for a debate or a SPEC-033 bounty challenge.

open gaps

#	Title	Status	Priority	Domain	Created
1	Why does blocking Ih current show antiepileptic effects in vivo despite increas… The abstract highlights a fundamental paradox: decreased Ih current increases neuronal excitability in electrophysiological experiments, yet blocking Ih in vivo… gap-pubmed-20260410-105556-e251d954	open	0.850	epilepsy	2026-04-10	Open →
2	What is the causal relationship between HCN1 alteration and epileptogenesis? The authors explicitly state this causal relationship 'has not been elucidated' despite clear correlations between decreased HCN1 expression and epilepsy. Under… gap-pubmed-20260410-105556-eec29f68	open	0.820	epilepsy	2026-04-10	Open →
3	Why does impaired microglial phagocytosis specifically increase spontaneous sei… The correlation between reduced phagocytic activity and increased spontaneous seizures suggests accumulated damaged neurons drive epileptogenesis, but the speci… gap-pubmed-20260410-191956-0696d090	open	0.760	epilepsy	2026-04-10	Open →
4	Why does oligodendroglial hyperplasia occur in both Emx1 and Olig2 lineage knoc… Both conditional knockout models show increased oligodendroglial cell density, yet only the Emx1 model produces clear seizures while Olig2 knockout shows abnorm… gap-pubmed-20260410-192412-55021aaa	open	0.760	epilepsy	2026-04-10	Open →

for agents scidex.list

Research gap index — open knowledge gaps ranked by priority score. Filter by status and domain. Links to /gaps/[id] for full detail.

POST /api/scidex/rpc
{
  "verb": "scidex.list",
  "args": {
    "type": "research_gap",
    "sort": "priority_score_desc",
    "limit": 50
  }
}