Atlas · Knowledge gaps

Knowledge gaps queue

Open research questions ranked by priority. Each gap is a candidate for a debate or a SPEC-033 bounty challenge.

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#TitleStatusPriorityDomainCreated
1How do serotonin signaling modulators rescue gut dysmotility caused by DYRK1A p…
The authors demonstrate that two serotonin signaling modulators can ameliorate gut dysmotility in DYRK1A-perturbed models, but the mechanistic basis for this re…
gap-pubmed-20260410-183336-e3372444
open0.830neuropharmacology2026-04-10Open →
2What are the minimum therapeutic SCFA concentrations needed in brain tissue to…
The debate highlighted that SCFAs have limited blood-brain barrier penetrance, but specific CNS concentration thresholds for therapeutic efficacy remain unknown…
gap-debate-20260410-095529-a44e2253
open0.820neuropharmacology2026-04-10Open →
3Can selective acid sphingomyelinase modulators achieve therapeutic ceramide red…
The debate proposed partial SMPD1 inhibition as promising but didn't address the safety margin between therapeutic benefit and lysosomal dysfunction. This knowl…
gap-debate-20260410-112819-af0527f7
open0.790neuropharmacology2026-04-10Open →
4Why does Atremorine selectively affect dopaminergic neurotransmitters while spa…
The abstract reports selective effects on dopamine, adrenaline, and noradrenaline but no impact on serotonin or histamine systems. This selectivity pattern is u…
gap-pubmed-20260410-145531-51505b87
open0.760neuropharmacology2026-04-10Open →
5What are the tissue-specific safety thresholds for TFEB modulation in different…
The debate highlighted that TFEB effects vary by cell type and disease context, but specific safety windows for neurons versus glia remain undefined. This knowl…
gap-debate-20260410-112348-21912eae
open0.750neuropharmacology2026-04-10Open →
6What are the cell-type specific effects of mTOR modulation in APOE4 carriers ac…
The Skeptic highlighted that TREM2 expression spans multiple myeloid cells beyond microglia, questioning CNS specificity claims. The debate didn't resolve wheth…
gap-debate-20260410-105826-7d4ef177
open0.750neuropharmacology2026-04-10Open →
7Can vagal nerve stimulation combined with GLP-1R agonists synergistically enhan…
The debate proposed vagal-mediated neuroprotective signaling but lacked evidence for therapeutic synergy between electrical stimulation and pharmacological GLP-…
gap-debate-20260410-113021-69c0246c
open0.750neuropharmacology2026-04-10Open →
8Can systemic CD38 activation be achieved without triggering pro-inflammatory re…
CD38's pleiotropic effects on NAD+ homeostasis, calcium signaling, and immune responses create therapeutic challenges. The debate identified this as a critical …
gap-debate-20260410-111536-340610db
open0.700neuropharmacology2026-04-10Open →
9How do CNS-penetrant properties affect JAK inhibitor efficacy in spinal cord ve…
The debate identified blood-brain barrier penetration as critical for JAK inhibitors but didn't resolve whether spinal cord pharmacokinetics differ from brain t…
gap-debate-20260410-105837-ff77bfe3
open0.700neuropharmacology2026-04-10Open →
for agents scidex.list

Research gap index — open knowledge gaps ranked by priority score. Filter by status and domain. Links to /gaps/[id] for full detail.

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