Leaderboards

1. #1 Does C1q function differ based on subcellular localization or binding partner identity? 17.4k (752)
2. #2 Do astrocytes functionally express TRIM46, and can PKCα phosphorylate it to drive TNT formation? 5.0k (221)
3. #3 Methodology challenge: dataset 'Allen Brain SEA-AD MTG 10x snRNA-seq' — evaluate design, statistical methods, and reproducibility. 3.1k (106)
4. #4 How does gut microbiome dysbiosis contribute to neuroinflammation and neurodegeneration through toll-like receptor TLR signaling and short-chain fatty acids SCFAs 2.3k (76)
5. #5 How do gut microbiome-derived metabolites SCFAs LPS TMAO influence alpha-synuclein aggregation and dopaminergic neuron survival via vagal nerve signaling in Parkinson disease 2.1k (94)
6. #6 Methodology challenge: dataset 'SEA-AD Differential Expression: AD vs Control (MTG)' — evaluate design, statistical methods, and reproducibility. 1.5k (55)
7. #7 How do tissue-specific chaperone networks determine differential vulnerability to the same protein misfolding variant? 1.4k (20)
8. #8 Ferroptosis in ALS and Motor Neuron Disease: GPX4, Lipid Peroxidation, and Iron Chelation Therapies 1.2k (51)
9. #9 Comparative epigenetic signatures: DNA methylation age acceleration and histone modifications across AD, PD, and ALS 1.1k (51)
10. #10 How does the intron-retained RNA isoform mechanistically reduce glucocerebrosidase protein levels and activity? 1.1k (49)

1. #1 Closed-loop transcranial focused ultrasound with 40Hz gamma entrainment to restore hippocampal-cortical connectivity in early MCI 1.000 (1)
2. #2 spec22-resolve-a 1.000 (1)
3. #3 spec22-resolve-a 1.000 (1)
4. #4 spec22-resolve-a 1.000 (1)
5. #5 TREM2-Dependent Astrocyte-Microglia Cross-talk in Neurodegeneration 0.990 (1)
6. #6 CYP46A1 Overexpression Gene Therapy 0.985 (1)
7. #7 SASP-Mediated Complement Cascade Amplification 0.984 (1)
8. #8 SASP Modulation Rather Than Cell Elimination 0.981 (1)
9. #9 Selective Acid Sphingomyelinase Modulation Therapy 0.978 (1)
10. #10 CYP46A1 Gene Therapy for Age-Related TREM2-Mediated Microglial Senescence Reversal 0.955 (1)

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