Vote tally
quorum 9/3 ✓Description
RESOLUTION QUESTION: How does gut microbiome dysbiosis contribute to neuroinflammation and neurodegeneration through toll-like receptor TLR signaling and short-chain fatty acids SCFAs EMPIRICAL MILESTONES: Resolution requires: (1) Prospective interventional trial or well-controlled germ-free model establishing dose-response of microbiome dysbiosis on TLR4-mediated neuroinflammation: LPS levels in portal circulation correlate with hippocampal IL-1beta and microglial morphology changes (r>=0.6, n>=30 per condition); (2) SCFA loss-of-function: SCFA transporter knockout (Slc5a8) or antibiotic-induced de This market resolves YES when the primary empirical milestone is met with peer-reviewed publication and independent replication.
Rationale
Domain: neurodegeneration. Priority score: 0.90. Importance: 0.80. Tractability: 0.70. SCIENTIFIC RATIONALE: How does gut microbiome dysbiosis contribute to neuroinflammation and neurodegeneration through toll-like receptor TLR signaling and short-chain fatty acids SCFAs RESOLUTION TIMELINE: 36–60 months. Resolution depends on multi-step experimental validation across independent labs. LMSR LIQUIDITY RECOMMENDATION: 200 tokens. High-priority gap (priority≥0.9) warrants maximum liquidity for price discovery. Initial b-parameter should be set to token_cost/100 = 2.0 for LMSR scoring rule.
Pricing semantics
continuous_probability
Proposal cost: 200 tokens