Version history

{
  "families": [
    {
      "domain": "neurodegeneration",
      "description": "Protein misfolding and aggregation (amyloid, tau, alpha-synuclein, TDP-43).",
      "family_label": "proteinopathy",
      "tag_patterns": [
        "protein_misfolding",
        "amyloid",
        "tauopathy",
        "alpha_synuclein",
        "TDP-43",
        "aggregation"
      ],
      "kg_predicates": [
        "invokes_mechanism"
      ]
    },
    {
      "domain": "neurodegeneration",
      "description": "Impaired mitochondrial function, oxidative phosphorylation, or mitophagy.",
      "family_label": "mitochondrial_dysfunction",
      "tag_patterns": [
        "mitochondria",
        "oxidative_stress",
        "mitophagy",
        "ROS",
        "OXPHOS"
      ],
      "kg_predicates": [
        "invokes_mechanism"
      ]
    },
    {
      "domain": "neurodegeneration",
      "description": "Microglial activation, astrocyte reactivity, cytokine signaling.",
      "family_label": "neuroinflammation",
      "tag_patterns": [
        "microglia",
        "neuroinflammation",
        "cytokine",
        "astrocyte",
        "inflammation"
      ],
      "kg_predicates": [
        "invokes_mechanism"
      ]
    },
    {
      "domain": "neurodegeneration",
      "description": "Blood-brain barrier breakdown, cerebral hypoperfusion, vascular pathology.",
      "family_label": "vascular",
      "tag_patterns": [
        "vascular",
        "BBB",
        "blood_brain_barrier",
        "hypoperfusion",
        "hemorrhage"
      ],
      "kg_predicates": [
        "invokes_mechanism"
      ]
    },
    {
      "domain": "neurodegeneration",
      "description": "Synaptic loss, neurotransmitter dysfunction, synaptic plasticity impairment.",
      "family_label": "synaptic",
      "tag_patterns": [
        "synaptic",
        "synapse",
        "neurotransmitter",
        "glutamate",
        "GABA",
        "dopaminergic"
      ],
      "kg_predicates": [
        "invokes_mechanism"
      ]
    },
    {
      "domain": "neurodegeneration",
      "description": "DNA methylation, histone modification, chromatin remodeling in neurodegeneration.",
      "family_label": "epigenetic",
      "tag_patterns": [
        "epigenetic",
        "methylation",
        "histone",
        "chromatin",
        "non_coding_RNA"
      ],
      "kg_predicates": [
        "invokes_mechanism"
      ]
    },
    {
      "domain": "neurodegeneration",
      "description": "Monogenic or polygenic risk variants driving neurodegenerative disease.",
      "family_label": "genetic",
      "tag_patterns": [
        "genetic",
        "mutation",
        "variant",
        "GWAS",
        "familial",
        "SNP"
      ],
      "kg_predicates": [
        "invokes_mechanism"
      ]
    },
    {
      "domain": "neurodegeneration",
      "description": "Metabolic pathway disruption (glucose metabolism, lipid metabolism, iron homeostasis).",
      "family_label": "metabolic",
      "tag_patterns": [
        "metabolic",
        "glucose",
        "lipid",
        "iron",
        "homeostasis",
        "insulin"
      ],
      "kg_predicates": [
        "invokes_mechanism"
      ]
    },
    {
      "domain": "neurodegeneration",
      "description": "Adaptive and innate immune responses in neurodegeneration (distinct from neuroinflammation).",
      "family_label": "immune",
      "tag_patterns": [
        "immune",
        "T_cell",
        "B_cell",
        "autoimmune",
        "complement",
        "antibody"
      ],
      "kg_predicates": [
        "invokes_mechanism"
      ]
    },
    {
      "domain": "neurodegeneration",
      "description": "Impaired autophagic clearance, lysosomal dysfunction, proteostasis failure.",
      "family_label": "autophagy",
      "tag_patterns": [
        "autophagy",
        "lysosomal",
        "proteostasis",
        "clearance",
        "ubiquitin"
      ],
      "kg_predicates": [
        "invokes_mechanism"
      ]
    }
  ],
  "version": 1,
  "diversity_threshold": 0.7,
  "diversity_bonus_max": 1.5,
  "diversity_min_entropy": 0.3,
  "lifecycle_state": "active"
}