All missions

Microglia / astrocyte / cytokine-driven neuroinflammation portfolio overlapping AD, PD, and ALS. v1 keeps it as a separate mission rather than nesting under each disease; v2 preserves that structure via the SPEC-027 §5 t…

Cross-cutting cellular-biology mission spanning AD, PD, and lysosomal-storage disease through TFEB / TFE3 / autophagy / mitophagy mechanisms. The canonical "multi-disease" mission that motivates SPEC-027 §8's many-to-man…

Hypothesis portfolio for SOD1, TDP-43, C9orf72, FUS, and motor-neuron disease mechanisms. Smallest v1 mission by raw hypothesis count but high evidence_quality on cited PMIDs; coverage_score reflects the depth-vs-breadth…

Hypothesis portfolio for alpha-synuclein, LRRK2, GBA, and mitochondrial dysfunction in PD. v1 has 252 scored PD hypotheses; v2 retains them as bound artifacts and adds the Mission Index Score's top-quartile component (SP…

Hypothesis portfolio targeting amyloid-beta, tau, microglial priming, and lipid metabolism in AD. Biggest v1 corpus segment with ~310 scored hypotheses; the v2 mission re-binds them via typed substrate links (SPEC-027 §5…