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open_questions › What resolves this contention: Functional effect of L2/3 onto L5 during sensory processing: a slice-mapping paper finds L2/3 supplies strong excitatory drive consistent with the canonical L2/3→L5 path, while the in-vivo barrel-cortex study finds that net activation of L2/3 suppresses rather than excites L5 spiking. The two differ on whether the dominant L2/3→L5 signal is excitatory or feed-forward-inhibitory in awake animals. / Contrary to standard models, activating L2/3 predominantly suppressed spontaneous activity in L5, whereas deactivating L2/3 mainly facilitated touch responses in L5. / Consistent with the canonical cortical microcircuit, layer 4 excitatory neurons and interneurons within L2/3 represented the most common sources of input to L2/3 pyramidal cells. › diff

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