Version history

{
  "field_tag": "excitatory-recurrence",
  "text": "What resolves this contention: Functional effect of L2/3 onto L5 during sensory processing: a slice-mapping paper finds L2/3 supplies strong excitatory drive consistent with the canonical L2/3→L5 path, while the in-vivo barrel-cortex study finds that net activation of L2/3 suppresses rather than excites L5 spiking. The two differ on whether the dominant L2/3→L5 signal is excitatory or feed-forward-inhibitory in awake animals. / Contrary to standard models, activating L2/3 predominantly suppressed spontaneous activity in L5, whereas deactivating L2/3 mainly facilitated touch responses in L5. / Consistent with the canonical cortical microcircuit, layer 4 excitatory neurons and interneurons within L2/3 represented the most common sources of input to L2/3 pyramidal cells.",
  "source_refs": [
    "paper:paper-14e5fb681943",
    "paper:paper-ec77beb36424",
    "wiki_page:computationalreviewrecurrence-02-anatomy-primer",
    "paper:paper-14e5fb681943",
    "paper:paper-ec77beb36424",
    "wiki_page:computationalreviewrecurrence-02-anatomy-primer",
    "wiki_page:computationalreviewrecurrence-04-translaminar",
    "paper:paper-14e5fb681943",
    "paper:paper-ec77beb36424",
    "wiki_page:computationalreviewrecurrence-02-anatomy-primer",
    "wiki_page:computationalreviewrecurrence-04-translaminar",
    "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
    "paper:paper-14e5fb681943",
    "paper:paper-ec77beb36424",
    "wiki_page:computationalreviewrecurrence-02-anatomy-primer",
    "wiki_page:computationalreviewrecurrence-04-translaminar",
    "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
    "paper:paper-14e5fb681943",
    "paper:paper-ec77beb36424",
    "wiki_page:computationalreviewrecurrence-02-anatomy-primer",
    "wiki_page:computationalreviewrecurrence-04-translaminar",
    "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
    "paper:paper-14e5fb681943",
    "paper:paper-ec77beb36424",
    "wiki_page:computationalreviewrecurrence-02-anatomy-primer",
    "wiki_page:computationalreviewrecurrence-04-translaminar",
    "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
    "paper:paper-14e5fb681943",
    "paper:paper-ec77beb36424",
    "wiki_page:computationalreviewrecurrence-02-anatomy-primer",
    "wiki_page:computationalreviewrecurrence-04-translaminar",
    "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
    "paper:paper-14e5fb681943",
    "paper:paper-ec77beb36424",
    "wiki_page:computationalreviewrecurrence-02-anatomy-primer",
    "wiki_page:computationalreviewrecurrence-04-translaminar",
    "wiki_page:computationalreviewrecurrence-07-celltype-motifs",
    "paper:paper-14e5fb681943",
    "paper:paper-ec77beb36424",
    "wiki_page:computationalreviewrecurrence-02-anatomy-primer",
    "wiki_page:computationalreviewrecurrence-04-translaminar",
    "wiki_page:computationalreviewrecurrence-07-celltype-motifs"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}