Version history

{
  "field_tag": "neuroscience",
  "text": "What resolves this contention: The normal role of PV basket cells in SWRs (strongly active) is selectively disrupted in AD models, suggesting disease-specific vulnerability of basket cells but not other PV+ subtypes - this challenges the view that all PV+ cells are equally affected in AD / Axo-axonic cells are inhibited during SWRs while PV basket cells strongly increase firing during SWRs in healthy hippocampus / In 5xFAD mice, PV basket cell activity is selectively reduced by 46% during SWRs while bistratified and axo-axonic cells are unimpaired",
  "source_refs": [
    "paper:paper-12b8963c5eea",
    "paper:paper-54726517a4fb",
    "wiki_page:computationalreviewpv-09",
    "paper:paper-12b8963c5eea",
    "paper:paper-54726517a4fb",
    "wiki_page:computationalreviewpv-09",
    "paper:paper-12b8963c5eea",
    "paper:paper-54726517a4fb",
    "wiki_page:computationalreviewpv-09"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}