Version history

{
  "field_tag": "basal-ganglia",
  "text": "What resolves this contention: Polarity and segregation of dSPN function: classical model assigns dSPNs a uniform motor-promoting role with direct-pathway monopoly, whereas dorsolateral dSPN stimulation suppresses movement and asymmetric inputs implicate D2-SPNs in driving direct-pathway elements. / In contrast to the canonical motor-promoting response of dSPNs in the dorsomedial striatum (DMSdSPNs), optogenetic stimulation of dSPNs in the dorsolateral striatum (DLSdSPNs) suppressed locomotion. / These results are consistent with the functional connectivity in which the excitatory inputs to D1-SPNs mostly drive the direct pathway, and the inputs to D2-SPNs target both the indirect and direct pathways ( Figure 3A ).",
  "source_refs": [
    "paper:paper-047f747899b8",
    "paper:paper-c9de2ec0f920",
    "wiki_page:computationalreviewloops-04",
    "paper:paper-047f747899b8",
    "paper:paper-c9de2ec0f920",
    "wiki_page:computationalreviewloops-04",
    "paper:paper-047f747899b8",
    "paper:paper-c9de2ec0f920",
    "wiki_page:computationalreviewloops-04"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}