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open_questions › What resolves this contention: Tension over the canonical 'function' of LHA orexin/hypocretin neurons: Adamantidis et al. frame them as a causal driver of arousal/wakefulness transitions, whereas the Goforth/Myers leptin work and broader feeding-circuit literature emphasize their integration of metabolic state and feeding/activity, with leptin actively suppressing them. The two frames assign primary causal weight to different functions of the same neuronal population. / We found that direct, selective, optogenetic photostimulation of Hcrt neurons increased the probability of transition to wakefulness from either slow wave sleep or rapid eye movement sleep. / Leptin inhibits lateral hypothalamic area (LHA) orexin (OX; also known as hypocretin)-producing neurons, which control feeding, activity, and energy expenditure, among other parameters. › diff

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