Version history

{
  "field_tag": "basal-ganglia",
  "text": "What resolves this contention: Tension over the canonical 'function' of LHA orexin/hypocretin neurons: Adamantidis et al. frame them as a causal driver of arousal/wakefulness transitions, whereas the Goforth/Myers leptin work and broader feeding-circuit literature emphasize their integration of metabolic state and feeding/activity, with leptin actively suppressing them. The two frames assign primary causal weight to different functions of the same neuronal population. / We found that direct, selective, optogenetic photostimulation of Hcrt neurons increased the probability of transition to wakefulness from either slow wave sleep or rapid eye movement sleep. / Leptin inhibits lateral hypothalamic area (LHA) orexin (OX; also known as hypocretin)-producing neurons, which control feeding, activity, and energy expenditure, among other parameters.",
  "source_refs": [
    "paper:paper-b28f49fb8c93",
    "paper:33ec7ac1-f3ee-4b0d-9f96-765915588694",
    "wiki_page:computationalreviewloops-09",
    "paper:paper-b28f49fb8c93",
    "paper:33ec7ac1-f3ee-4b0d-9f96-765915588694",
    "wiki_page:computationalreviewloops-09",
    "paper:paper-b28f49fb8c93",
    "paper:33ec7ac1-f3ee-4b0d-9f96-765915588694",
    "wiki_page:computationalreviewloops-09"
  ],
  "importance": "0.7200",
  "tractability": "0.5500",
  "potential_impact": "0.7000",
  "composite_score": "0.2772",
  "elo_rating": "1500.00",
  "state": "open",
  "decay_rate": "0.01000",
  "resolution_evidence_refs": []
}